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One of the main disadvantages of inhalation therapy of (preterm) neonates during respiratory support is the low delivery efficiency. Due to the high breathing frequency, short inspiration time and low tidal volume of (preterm) neonates, there is currently no highly efficient breath-triggered drug release directly inside the patient interface (nasal prong) available. Therefore, the research institute developed a breath-triggered drug release system using a nasal prong with an integrated valve to increase the efficiency of inhaled aerosol. The abdominal wall movement during breathing serves as trigger signal for the breath-triggered release of pharmaceutical aerosols.
This system enhances aerosol delivery by at least a factor of 4 compared to non-triggered systems. It also allows targeted delivery of aerosol boluses at different inspiration times targeting different lung areas.
Furthermore, there are no suitable test methods on the market for performance testing of inhalers for the use in ventilated (preterm) neonates. In this context, the research institute, together with a well-known medical device manufacturer, has developed an appropriate test bench for the evaluation and characterisation of the new inhalator platform.
The institute is now looking for industrial partners for collaborations under a commercial agreement with technical assistance. In this context, the research institute is keen to collaborate with suitable companies in order to prepare the market entry of the presented innovations. They are looking to get in contact with companies who are capable of turning medical innovations from R&D-projects into market-ready products.
Additionally, the institute is offering the innovative technologies for licensing. Suitable partners could be experienced manufacturers or other SMEs from the field of medical devices.
Furthermore, they are keen to collaborate in joint research projects with suitable SMEs and R&D institutions in order to further develop the presented innovations. The cooperation partner should be an experienced research insitute which should preferably already be active in research regarding inhaled aerosols.
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